Publications by authors named "Alexander J Simmons"
Article Synopsis
- The extracellular matrix (ECM) in skeletal muscle is crucial for tissue development, support, and force transmission, and adapts through remodeling in response to mechanical loading.
- Recent research on older adults indicated that genes important for ECM remodeling, particularly MMP14, were significantly upregulated after 14 weeks of progressive resistance exercise training.
- A study using single-cell RNA-seq showed that muscle fibers can influence macrophages to enhance MMP14 expression and promote ECM remodeling, establishing a functional connection between muscle activity and immune response in the context of exercise.
