Publications by authors named "Alexander J Hose"
A higher diversity of food items introduced in the first year of life has been inversely related to subsequent development of asthma. In the current analysis, we applied latent class analysis (LCA) to systematically assess feeding patterns and to relate them to asthma risk at school age. PASTURE (N=1133) and LUKAS2 (N=228) are prospective birth cohort studies designed to evaluate protective and risk factors for atopic diseases, including dietary patterns.
View Article and Find Full Text PDFBackground: The prevalence of atopy is associated with a Western lifestyle, as shown by studies comparing neighboring regions with different socioeconomic backgrounds. Atopy might reflect various conditions differing in their susceptibility to environmental factors.
Objective: We sought to define phenotypes of atopic sensitization in early childhood and examine their association with allergic diseases and hereditary background in Finland and Estonia.
Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts.
J Allergy Clin Immunol
June 2017
Article Synopsis
- The study aimed to define childhood atopy phenotypes over the first 6 years by analyzing allergen specificity, time course, and levels of specific IgE in children.
- Using latent class analysis (LCA) on two large cohorts, researchers identified distinct groups of atopy, including a severe phenotype linked to high sIgE levels and a greater risk of asthma and other atopic diseases.
- The findings suggest that excessive production of specific IgE early in life is a strong predictor of asthma risk and correlated with compromised lung function, indicating a dysbalanced immune response in affected children.
The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.
Am J Respir Crit Care Med
April 2016
Rationale: Growing up on a farm protects from childhood asthma and early wheeze. Virus-triggered wheeze in infancy predicts asthma in individuals with a genetic asthma risk associated with chromosome 17q21.
Objectives: To test environmental determinants of infections and wheeze in the first year of life, potential modifications of these associations by 17q21, and the implications for different trajectories of wheeze.
Background: Breast-feeding is protective against respiratory infections in early life. Given the co-evolutionary adaptations of humans and cattle, bovine milk might exert similar anti-infective effects in human infants.
Objective: To study effects of consumption of raw and processed cow's milk on common infections in infants.