Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson's Disease.

Background: Abnormal synchronization of neuronal activity in dopaminergic circuits is related to motor impairment in Parkinson's disease (PD). Vibrotactile coordinated reset (vCR) fingertip stimulation aims to counteract excessive synchronization and induce sustained unlearning of pathologic synaptic connectivity and neuronal synchrony. Here, we report two clinical feasibility studies that examine the effect of regular and noisy vCR stimulation on PD motor symptoms.

A Single Case Feasibility Study of Sensorimotor Rhythm Neurofeedback in Parkinson's Disease.

Electroencephalographic activity over the sensorimotor cortex has been one of the best studied targets for neurofeedback therapy. Parkinson's disease patients display abnormal brain rhythms in the motor cortex caused by increased synchrony in the basal ganglia-cortical pathway. Few studies have examined the effects of sensorimotor-based neurofeedback therapy in humans with PD.

EEG Correlates of Involuntary Cognitions in the Reflexive Imagery Task.

The Reflexive Imagery Task (RIT) reveals that the activation of sets can result in involuntary cognitions that are triggered by external stimuli. In the basic RIT, subjects are presented with an image of an object (e.g.