Publications by authors named "Alexander Ioffe"
MARIA (magnetism reflectometer with high incident angle) is a world class vertical sample reflectometer dedicated to the investigation of thin films in the fields of magnetism, soft matter and biology. The elliptical vertically focusing guide allows one to measure small samples with a typical size of 1 × 1 cm very efficiently. The double-bounce polarizer and the pumped He SEOP (spin-exchange optical pumping) neutron spin filter cell for analysing the polarization of the reflected neutron beam can be moved into the beam in seconds.
View Article and Find Full Text PDFStudies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles.
Colloids Surf B Biointerfaces
January 2018
Article Synopsis
- Understanding the molecular mechanisms of drug adsorption/desorption is crucial for designing effective pharmaceutical formulations using superparamagnetic iron oxide nanoparticles (SPIONs) in biomedical applications.
- Research on the cytostatic drug Mitoxantrone (MTO) revealed that its adsorption to lauric acid-albumin hybrid coated SPIONs (SEON) enhances stability and sustainable drug release compared to uncoated nanoparticles and protein solutions.
- Techniques like FTIR, DLS, and neutron/X-ray scattering were employed to study MTO interactions with SEON, indicating that MTO molecules are located on the outer surface of the nanoparticle coating, affecting their repulsive interactions.
Spherical high density lipoprotein (sHDL), a key player in reverse cholesterol transport and the most abundant form of HDL, is associated with cardiovascular diseases. Small angle neutron scattering with contrast variation was used to determine the solution structure of protein and lipid components of reconstituted sHDL. Apolipoprotein A1, the major protein of sHDL, forms a hollow structure that cradles a central compact lipid core.
View Article and Find Full Text PDFArticle Synopsis
- The study utilized over 80 ns of molecular dynamics simulation to explore the structure and behavior of the Double-Super Helix (DSH) model of nascent high-density lipoprotein (HDL) and compared the findings with various experimental methods.
- Experimental data from techniques like small-angle neutron scattering and nuclear magnetic resonance showed good agreement with simulation results, supporting key structural features of the DSH model, such as the superhelical apoA1 chains and micellar lipid organization.
- This research highlights the effectiveness of combining simulations with experimental approaches to understand the complex structure of lipoproteins, validating the DSH model and revealing new details about nascent HDL.