Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines.

Purpose: Papillary thyroid cancer (PTC) has a high incidence of BRAF mutation. The purpose of this study was to evaluate the potential relationship between thyroiditis and BRAF mutation status in patients with PTC. We investigated how a selective inhibitor of BRAF PLX4032 affects the proliferation and inflammatory cytokine levels of thyroid cancer.

Prognostic Significance of Prostaglandin-Endoperoxide Synthase-2 Expressions in Human Breast Carcinoma: A Multiomic Approach.

Prostaglandin-endoperoxide synthase-2 () plays a pivotal role in inflammation and carcinogenesis in human breast cancer. Our aim of the study is to find the prognostic value of in breast cancer. We conducted a multiomic analysis to determine whether functions as a prognostic biomarker in human breast cancer.

High-resolution dental magnetic resonance imaging for planning palatal graft surgery-a clinical pilot study.

Aim: To evaluate whether high-resolution, non-contrast-enhanced dental magnetic resonance imaging (MRI) can be used for accurate determination of palatal masticatory mucosa thickness (PMMT) and to locate the greater palatal artery (GPA).

Materials And Methods: In five volunteers (four males, one female; mean age 30.2 ± 0.

Determination of the palatal masticatory mucosa thickness by dental MRI: a prospective study analysing age and gender effects.

Objectives: The aim of this prospective study was to evaluate age and gender effects on the palatal masticatory mucosa thickness by using non-invasive and non-ionizing MRI.

Methods: 40 periodontally healthy participants of five gender-balanced age groups (20-29, 30-39, 40-49, 50-59 and 60-69 years, respectively) underwent dental MRI at 3 Tesla using a contrast-enhanced, high-resolution 3D-sequence. The palatal masticatory mucosa was measured at 40 standard measurement points by two independent observers.

PETRA, MSVAT-SPACE and SEMAC sequences for metal artefact reduction in dental MR imaging.

Objectives: Dental MRI is often impaired by artefacts due to metallic dental materials. Several sequences were developed to reduce susceptibility artefacts. Here, we evaluated a set of sequences for artefact reduction for dental MRI for the first time.

Lateral cephalometric analysis for treatment planning in orthodontics based on MRI compared with radiographs: A feasibility study in children and adolescents.

Objective: The objective of this prospective study was to evaluate whether magnetic resonance imaging (MRI) is equivalent to lateral cephalometric radiographs (LCR, "gold standard") in cephalometric analysis.

Methods: The applied MRI technique was optimized for short scanning time, high resolution, high contrast and geometric accuracy. Prior to orthodontic treatment, 20 patients (mean age ± SD, 13.

Artefacts of implant-supported single crowns - Impact of material composition on artefact volume on dental MRI.

Purpose: MRI allows radiation-free imaging of the head and neck area. However, implant-supported prostheses may severely impair image quality due to artefacts. Therefore, identification of preferable material compositions for implants and supported prostheses with little impact on MR image quality is mandatory.

Superior in vitro stimulation of human CD8+ T-cells by whole virus versus split virus influenza vaccines.

Pandemic and seasonal influenza viruses cause considerable morbidity and mortality in the general human population. Protection from severe disease may result from vaccines that activate antigen-presenting DC for effective stimulation of influenza-specific memory T cells. Special attention is paid to vaccine-induced CD8+ T-cell responses, because they are mainly directed against conserved internal influenza proteins thereby presumably mediating cross-protection against circulating seasonal as well as emerging pandemic virus strains.