TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.

Background: Mutations in the transient receptor potential channel 6 () gene are associated with an inherited form of FSGS. Despite widespread expression, patients with mutations do not present with any other pathologic phenotype, suggesting that this protein has a unique yet unidentified role within the target cell for FSGS, the kidney podocyte.

Methods: We generated a stable knockout podocyte cell line from knockout mice.