Publications by authors named "Alexander Georgoulopoulos"
Article Synopsis
- The study analyzed data from 886 patients involved in the CALYPSO trial to explore how early declines in cancer antigen 125 (CA125) and early tumor responses serve as predictors for the effectiveness of two cancer treatments: carboplatin-pegylated liposomal doxorubicin (CPLD) versus carboplatin-paclitaxel (CP).
- It found that an early decline in CA125 levels correlated with better progression-free survival (PFS), but early tumor responses did not show a significant association.
- While CPLD improved PFS compared to CP, a lower percentage of CPLD patients experienced early decline or early response, indicating that these measures are not reliable indicators of treatment success.
Objective: To show that the fetal outcome in vaginal deliveries (VD) of breech presentation in a setting of a senior obstetrician stand-by system is as good as in planned cesarean sections.
Patients And Methods: This observational prospective intent-to-treat study (n=211 singleton breech presentation pregnancies of ≥35 weeks of gestation) compared two groups of breech deliveries: planned cesarean sections (PCS, n=126) and intended VD (IVD, n=85) resulting in vaginal deliveries (VD, n=46) as well as secondary cesarean sections (SCS, n=39). Women's informed choice as well as strict pre-selection criteria for vaginally intended breech presentation deliveries was followed.
Objective: We sought to determine the validity of colposcopically directed cervical biopsies as a diagnostic test to define the degree of cervical intraepithelial neoplasia (CIN).
Study Design: In a prospective multicenter trial, patients undergoing excisional procedures of the transformation zone additionally had colposcopy and up to 3 guided cervical biopsies in a single procedure. Cervical biopsies were regarded as a diagnostic test to detect high-grade lesions (CIN 2,3), with the cone specimen as reference standard.