Publications by authors named "Alexander G Theofiles"
Article Synopsis
- Subcutaneous phaeohyphomycosis usually affects healthy individuals after trauma but can become severe in people with CARD9 deficiencies or those who have had transplants due to unclear protective mechanisms.
- A patient with a severe case of this infection harbored harmful mutations in the CLEC7A gene, leading to impaired immune responses against the fungus Corynespora cassiicola.
- Research using a mouse model revealed that both Dectin-1 and CARD9 are crucial for producing key immune signals (TNF-α and IL-1β) that help kill this fungus, and a study of additional patients showed that many had similar mutations affecting immune function.
Objective: To describe clinical and laboratory findings from the 2012 southeastern Minnesota pertussis outbreak.
Patients And Methods: Patients were selected for 2 parts of the study. In the first part, nasopharyngeal swabs from a convenience sample of 265 unique patients were used for both the clinician-requested polymerase chain reaction (PCR) test and culture.
Background: In the face of changing environmental conditions, the mechanisms underlying stress responses in diverse organisms are of increasing interest. In vertebrates, Drosophila, and Caenorhabditis elegans, FoxO transcription factors mediate cellular responses to stress, including oxidative stress and dietary restriction. Although FoxO genes have been identified in early-arising animal lineages including sponges and cnidarians, little is known about their roles in these organisms.
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