Publications by authors named "Alexander G Smith"
Although Cu is ubiquitous, the relativistic destabilization of the 5d orbitals makes the isoelectronic Au exceedingly rare, typically stabilized only through Au-Au bonding or by using redox non-innocent ligands. Here we report the perovskite CsAuAuCl, an extended solid with mononuclear Au sites, which is stable to ambient conditions and characterized by single-crystal X-ray diffraction. The 2+ oxidation state of Au was assigned using Au Mössbauer spectroscopy, electron paramagnetic resonance, and magnetic susceptibility measurements, with comparison to paramagnetic and diamagnetic analogues with Cu and Pd, respectively, as well as to density functional theory calculations.
View Article and Find Full Text PDFMetabolomic Profiling of Cholesterol Efflux Capacity in a Multiethnic Population: Insights From MESA.
Arterioscler Thromb Vasc Biol
October 2023
Article Synopsis
- The study investigates how various circulating metabolites relate to cholesterol efflux capacity (CEC), which is linked to cardiovascular disease.
- A total of 3,543 participants from the MESA study were analyzed, revealing that larger-sized VLDL and HDL particles, along with their components, showed a significant association with higher CEC.
- Despite these associations, the ability to predict CEC using metabolite profiles was low, with race being a significant factor, as Black participants demonstrated lower CEC compared to other racial groups.
Mitochondrial respiratory chain dysfunction causes a variety of life-threatening diseases affecting about 1 in 4300 adults. These diseases are genetically heterogeneous, but have the same outcome; reduced activity of mitochondrial respiratory chain complexes causing decreased ATP production and potentially toxic accumulation of metabolites. Severity and tissue specificity of these effects varies between patients by unknown mechanisms and treatment options are limited.
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