Publications by authors named "Alexander Edward Lipka"
The total sugarcane (Saccharum L.) production has increased worldwide; however, the rate of growth is lower compared with other major crops, mainly due to a plateauing of genetic gain. Genomic selection (GS) has proven to substantially increase the rate of genetic gain in many crops.
View Article and Find Full Text PDFArticle Synopsis
- Many breast cancer deaths come from women with recurrent, estrogen receptor-positive tumors, highlighting the need for new treatment methods to make these tumors more sensitive to endocrine therapies.
- This study focused on validating certain nuclear transport genes, particularly XPO1, as potential indicators of endocrine therapy failure and explored how inhibiting XPO1 could enhance endocrine treatments.
- Results indicated that high levels of XPO1 were linked to poor survival rates and tamoxifen resistance, but combining XPO1 inhibition with tamoxifen restored sensitivity and reduced recurrence in resistant cancer models.