Publications by authors named "Alexander E St John"
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Synopsis of recent research by authors named "Alexander E St John"
- Alexander E St John focuses on the interplay between immune cell inflammation and coagulopathy, particularly during trauma-induced conditions, examining how leukocyte activation and oxidative stress affect fibrinogen function and overall hemostasis.
- His research employs advanced techniques such as single-cell imaging flow cytometry and high-dimensional immunophenotyping to investigate the mechanisms behind trauma-induced coagulopathy, revealing critical insights into fibrinogen consumption and platelet dysfunction.
- St John's work also explores innovative therapeutic approaches, such as the use of a melanocortin fusion protein and topical tranexamic acid formulations to mitigate bleeding and improve outcomes in trauma cases, emphasizing the need for effective strategies in resuscitation and hemorrhage control.
