Publications by authors named "Alexander D Morris"
Article Synopsis
- The study investigates a method to activate the immune response in cancer cells, particularly in "cold" tumors, by targeting a protein called DHX9 which suppresses the presence of double-stranded RNA (dsRNA).
- By depleting DHX9 in small cell lung cancer (SCLC) cells, researchers observed an increase in cytoplasmic dsRNA and R-loops, leading to enhanced innate immunity and reduced tumor growth.
- The findings suggest that targeting DHX9 could turn tumors more responsive to immunotherapy, offering a new strategy for treating SCLC and other tumors characterized by genomic instability.
