A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.

Unlabelled: Although localized prostate cancer is relatively indolent, advanced prostate cancer manifests with aggressive and often lethal variants, including neuroendocrine prostate cancer (NEPC). To identify drivers of aggressive prostate cancer, we leveraged transposon mutagenesis in a mouse model based on prostate-specific loss-of-function of and . Compared with control mice, mice developed more aggressive prostate tumors, with increased incidence of metastasis.

Instrumented insoles for assessment of gait in patients with vestibular schwannoma.

Background: Imbalance and gait disturbances are common in patients with vestibular schwannoma (VS) and can result in significant morbidity. Current methods for quantitative gait analysis are cumbersome and difficult to implement. Here, we use custom-engineered instrumented insoles to evaluate the gait of patients diagnosed with VS.