Publications by authors named "Alexander Chowdhury"
Article Synopsis
- Medical AI has the potential to enhance healthcare by improving evidence-based practice, personalizing treatment, cutting costs, and enhancing experiences for providers and patients.
- MedPerf is introduced as an open platform designed for benchmarking medical AI models, enabling federated evaluation across healthcare organizations while maintaining data privacy.
- The text outlines the challenges in healthcare AI, highlights the design and current status of MedPerf, and calls for collaboration from researchers and organizations to advance the platform.
Article Synopsis
- Immune checkpoint inhibitors (ICI) improve survival in non-small-cell lung cancer (NSCLC), but many patients eventually develop acquired resistance (AR), with underlying mechanisms largely unknown.
- The study analyzed tumor biopsies from 82 NSCLC patients who developed AR after ICI treatment, using techniques like genomic profiling and immunophenotyping, and compared them to control patients who received other treatments.
- Results showed that AR was linked to specific mutations in about 27.8% of patients, significant reductions in certain immune cells and HLA class I expression, pointing to the complex nature of resistance that must be addressed in future therapies.
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this study, we applied artificial intelligence methods to clinical data from 6 million patients (24,000 pancreatic cancer cases) in Denmark (Danish National Patient Registry (DNPR)) and from 3 million patients (3,900 cases) in the United States (US Veterans Affairs (US-VA)). We trained machine learning models on the sequence of disease codes in clinical histories and tested prediction of cancer occurrence within incremental time windows (CancerRiskNet).
View Article and Find Full Text PDFIntroduction: The lungs have three main fissures: the right oblique fissure (ROF), right horizontal fissure (RHF), and left oblique fissure (LOF). These can be complete, incomplete or absent; quantifying the degree of completeness of these fissures is novel. Standard textbooks often refer to the fissures as complete, but awareness of variation is essential in thoracic surgery.
View Article and Find Full Text PDFA deliberate attack involving chemical, biological, radiological, or nuclear (CBRN) material has the potential to cause substantial fear among the public. This presents problems for communicators, who will need to provide information quickly after an attack while ensuring that their messages are easily understood and likely to be attended to by members of the public. Identifying in advance what people would want to know, where they would get information from, and how messages should be presented might allow communicators to ensure that their messages have the best chance of having their desired effect.
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