Publications by authors named "Alexander Briones"

Article Synopsis
  • A study was conducted in 15 hospitals across Peru from July 2017 to October 2019 to collect data on antimicrobial resistance in gram-negative bacteria (GNB), as existing data was lacking.
  • Out of 449 collected blood culture isolates, 59.2% showed resistance to third-generation cephalosporins, and 16.5% displayed carbapenem resistance, with significant variations among different bacterial species.
  • The study found that 63.3% of empiric treatments effectively covered the causative GNB, but the in-hospital death rate was high at 33.3%, particularly linked to Pseudomonas aeruginosa and carbapenem-resistant infections.
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Correct processing of blood cultures may impact individual patient management, antibiotic stewardship, and scaling up of antimicrobial resistance surveillance. To assess the quality of blood culture processing, we conducted four assessments at 16 public hospitals across different regions of Peru. We assessed the following standardized quality indicators: 1) positivity and contamination rates, 2) compliance with recommended number of bottles/sets and volume of blood sampled, 3) blood culture utilization, and 4) possible barriers for compliance with recommendations.

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We characterized the antimicrobial resistance of 70 Escherichia coli isolates obtained from patients with a urinary tract infection (UTI) from 8 public hospitals in Peru. Resistance profiles were identified using the automated MicroScan® system. A standard polymerase chain reaction was used for the detection of the bla TEM, bla CTX-M, bla SHV and bla PER genes.

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Here we report the first incidence of New Delhi metallo-β-lactamase (NDM-1)-producing in Peru, identified via a strain-based nosocomial surveillance project carried out in Lima and Iquitos. The gene was detected by multiplex polymerase chain reaction (PCR) and confirmed by loci sequencing. is a nearly ubiquitous and promiscuous nosocomial pathogen, and the acquisition of by may facilitate an increase in the prevalence of this important resistance marker in other nosocomial pathogens.

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