Development of an automated manufacturing process for large-scale production of autologous T cell therapies.

Engineered T cell therapies have shown significant clinical success. However, current manufacturing capabilities present a challenge in bringing these therapies to patients. Furthermore, the cost of development and manufacturing is still extremely high due to complexity of the manufacturing process.

The CO-rich atmosphere of a young accreting super-Jupiter.

Isotope abundance ratios have an important role in astronomy and planetary sciences, providing insights into the origin and evolution of the Solar System, interstellar chemistry and stellar nucleosynthesis. In contrast to deuterium/hydrogen ratios, carbon isotope ratios are found to be roughly constant (around 89) in the Solar System, but do vary on galactic scales with a C/C isotopologue ratio of around 68 in the current local interstellar medium. In molecular clouds and protoplanetary disks, CO/CO ratios can be altered by ice and gas partitioning, low-temperature isotopic ion-exchange reactions and isotope-selective photodissociation.

Using a coherent hydrophone array for observing sperm whale range, classification, and shallow-water dive profiles.

Sperm whales in the New England continental shelf and slope were passively localized, in both range and bearing, and classified using a single low-frequency (<2500 Hz), densely sampled, towed horizontal coherent hydrophone array system. Whale bearings were estimated using time-domain beamforming that provided high coherent array gain in sperm whale click signal-to-noise ratio. Whale ranges from the receiver array center were estimated using the moving array triangulation technique from a sequence of whale bearing measurements.