Publications by authors named "Alexander Belka"
Article Synopsis
- Long noncoding RNAs (lncRNAs) are prevalent in the genome, but their functions are not well understood, partly due to their overlap with other genetic sequences.
- The researchers developed a new genome-scale screening method using Cas13d/CasRx to explore lncRNAs more effectively, overcoming limitations of previous methods.
- They created a targeted library called Albarossa, focusing on 24,171 lncRNA genes, which improves the ability to discover important lncRNAs across various cancers while addressing challenges like transcriptome size and tissue specificity.
Basal progenitors (BPs), including intermediate progenitors and basal radial glia, are generated from apical radial glia and are enriched in gyrencephalic species like humans, contributing to neuronal expansion. Shortly after generation, BPs delaminate towards the subventricular zone, where they further proliferate before differentiation. Gene expression alterations involved in BP delamination and function in humans are poorly understood.
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