Publications by authors named "Alexander B Dinitzen"
MicroRNAs (miRs) are small noncoding RNAs that regulate gene expression posttranscriptionally by binding to the 3' untranslated regions of their target mRNAs. The evolutionarily conserved microRNA-125a (miR-125a) is highly expressed in both murine and human hematopoietic stem cells (HSCs), and previous studies have found that miR-125 strongly enhances self-renewal of HSCs and progenitors. In this study we explored whether temporary overexpression of miR-125a would be sufficient to permanently increase HSC self-renewal or, rather, whether persistent overexpression of miR-125a is required.
View Article and Find Full Text PDFWater mobility in cancer cells could be a powerful parameter to predict the progression or remission of tumors. In the present descriptive work, new insight into this concept was achieved by combining neutron scattering and thermal analyses. The results provide the first step to untangle the role played by water dynamics in breast cancer cells (MCF-7) after treatment with a chemotherapy drug.
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- Effective mutation assessment methods are crucial for using genome sequencing in diagnosing diseases, but current techniques struggle with the large variety of mutations found in genomes.* -
- This study successfully applies new methods like saturation mutagenesis and biophysical modeling to predict how mutations in the MSH2 protein contribute to the hereditary cancer risk of Lynch syndrome.* -
- The findings reveal that many MSH2 mutations cause problems with protein folding and stability rather than directly losing function, suggesting that advanced modeling can improve predictions of disease-causing mutations compared to traditional approaches.*