Clinical Applicability of Tissue Polypeptide Antigen and CA-125 in Gynecological Malignancies.

Background: Nowadays there still is no sufficient screening tool for ovarian and uterine cancer.

Objective: The current study aimed to investigate whether cancer antigen 125 (CA-125), tissue polypeptide antigen (TPA) or the combination of both markers are able to act as screening tools for ovarian or uterine cancer.

Methods: A total of 275 blood samples from different cohorts (ovarian cancer, uterine cancer, benign control group) were prospectively drawn and analyzed.

Immunogenic Biomarkers HMGB1 and sRAGE Are Potential Diagnostic Tools for Ovarian Malignancies.

Background: High mobility group box 1 (HMGB1), soluble receptor of advanced glycation end products (sRAGE) and programmed cell death markers PD-1 and PD-L1 are immunogenic serum biomarkers that may serve as novel diagnostic tools for cancer diagnosis.

Methods: We investigated the four markers in sera of 231 women, among them 76 with ovarian cancer, 87 with benign diseases and 68 healthy controls, using enzyme immunoassays. Discrimination between groups was calculated using receiver operating characteristic (ROC) curves and sensitivities at fixed 90% and 95% specificities.

Soluble High Mobility Group Box 1 (HMGB1) Is a Promising Biomarker for Prediction of Therapy Response and Prognosis in Advanced Lung Cancer Patients.

Background: High mobility group box 1 protein (HMGB1) is known for its significant elevation in a multitude of tumors and benign diseases. In this study, we investigated the relevance of soluble HMGB1 for the prediction and monitoring of therapy response as well as the estimation of prognosis in advanced lung cancer.

Materials And Methods: In a retrospective study, HMGB1 levels were assessed by an enzyme-linked immunosorbent assay (ELISA) in the sera of 96 patients with advanced lung cancer (79 non-small-cell lung carcinoma (NSCLC); 14 small cell lung carcinoma (SCLC), 3 Mesothelioma) prior to cycles 1, 2, and 3 of chemotherapy and correlated with radiological therapy response after 2 and 4 cycles as well as with overall survival.

Ionic Liquids with Weakly Coordinating [M(III)(OR(F))4](-) Anions.

Ionic liquids (ILs) are defined as salts with melting points below 100 °C. They attracted much attention in the last two decades due to their unique set of properties, including high conductivities, low viscosities, negligible vapor pressure, and high electrochemical resistance. ILs are seen as tunable systems, of which (also in mixtures) up to 10(19) combinations may exist.

Effect of Dimethyl Carbonate on the Dynamic Properties and Ionicities of Ionic Liquids with [M(III) (hfip)4 ](-) (M=B, Al) Anions.

Several ionic liquids (ILs) comprising [B(hfip)4 ](-) [hfip=OCH(CF3 )2 ] or [Al(hfip)4 ](-) anions and imidazolium or ammonium cations were prepared and mixed with up to 270 mol % of dimethyl carbonate (DMC). The viscosities, conductivities, and self-diffusion constants of these mixtures and, where possible, of the neat ILs were measured and compared with common [NTf2 ](-) based ILs and their mixtures with DMC. A tremendous decrease of the viscosities and a likewise increase of the conductivities and diffusion constants can be achieved for all classes of ILs.

New water-stable ionic liquids based on tetrakis-(2,2,2-trifluoroethoxy)borate.

Several new ionic liquids (ILs) were prepared from Na[B(tfe)4] (tfe=OCH2 CF3 ) via metathesis, including one room temperature IL (RTIL). Prior to synthesis, suitable cations were chosen via predictive quantum-chemical calculations. Nuclear magnetic resonance monitoring over almost a month showed a total stability of the anion in the presence of water.