Publications by authors named "Alexander Augusto Martinez"
Article Synopsis
- Researchers studied 78 recently diagnosed, ART-naïve HIV subjects to investigate low-frequency mutations linked to drug resistance and virologic failure (VF).
- Using next-generation sequencing (NGS), they detected rare resistance mutations in 13 of 22 subjects who experienced VF, which were previously missed by conventional Sanger sequencing.
- No mutations were found against Integrase Strand Transfer Inhibitors (INSTIs), marking the study as a pioneering effort to identify pre-existing drug resistance in minority variants among ART-naïve individuals in the country.
Despite the effectiveness of current hepatitis B virus (HBV) vaccines, it is estimated that 350 million individuals suffer from chronic HBV infection and more than 50% of these affected individuals live on the Asian continent. Panama is a country with a great diversity of foreign groups; the Chinese community is a large example of this phenomenon. There is an urgent need to perform studies that evaluate the prevalence and the genetic diversity of HBV in this community.
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