Publications by authors named "Alexander Artamonov"
Article Synopsis
- tRNA-derived fragments (tRFs) serve both as biomarkers and signaling molecules in various disorders, with their expression patterns differing among blood cell types and changing with physiological conditions, such as during COVID-19.
- The research compared tRF expression in different blood cells (erythrocytes, monocytes, lymphocytes, etc.) from both healthy donors and severe COVID-19 patients using fluorescence sorting and next-generation sequencing.
- The study found significant changes in tRF patterns in multiple cell types during severe COVID-19, indicating that distinct blood cells respond differently to cytokine storms, which may involve regulation through nucleotide modifications and RNA enzyme activity alterations.
Non-coding RNA expression has shown to have cell type-specificity. The regulatory characteristics of these molecules are impacted by changes in their expression levels. We performed next-generation sequencing and examined small RNA-seq data obtained from 6 different types of blood cells separated by fluorescence-activated cell sorting of severe COVID-19 patients and healthy control donors.
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- - The study aimed to compare responses from GPT-4 with a consensus statement on diagnosing and managing anterior shoulder instability (ASI) to evaluate the AI's reliability in this context.
- - Responses from GPT-4 were rated for similarity to expert opinions, showing high concordance (25.8% high similarity) but also notable discrepancies (41.9% disagreement). GPT-4 rated its own responses more favorably than the surgeons did.
- - The findings suggest that while GPT-4 can provide relevant information, its responses do not closely align with expert recommendations, highlighting the need for caution in using AI for medical guidance.
Severe COVID-19 alters the biochemical and morphological characteristics of blood cells in a wide variety of ways. To date, however, the vast majority of research has been devoted to the study of leukocytes, while erythrocyte morphological changes have received significantly less attention. The aim of this research was to identify erythrocyte morphology abnormalities that occur in COVID-19, compare the number of different poikilocyte types, and measure erythrocyte sizes to provide data on size dispersion.
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- The study reports on the outcomes of subacromial balloon spacer implantation (SBSI) over a minimum of 5 years, focusing on survivorship, pain reduction, functional improvements, complications, and the need for reoperations.
- Out of 36 patients who underwent SBSI, 29 had follow-up data, showing significant improvements in patient-reported scores for pain, strength, and overall satisfaction.
- The results indicate that pain and function improvements are maintained over time, with a 13.79% conversion rate to reverse total shoulder arthroplasty.