A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening.

High-content imaging for compound and genetic profiling is popular for drug discovery but limited to endpoint images of fixed cells. Conversely, electronic-based devices offer label-free, live cell functional information but suffer from limited spatial resolution or throughput. Here, we introduce a semiconductor 96-microplate platform for high-resolution, real-time impedance imaging.

A semiconductor 96-microplate platform for electrical-imaging based high-throughput phenotypic screening.

Profiling compounds and genetic perturbations via high-content imaging has become increasingly popular for drug discovery, but the technique is limited to endpoint images of fixed cells. In contrast, electronic-based devices offer label-free, functional information of live cells, yet current approaches suffer from low-spatial resolution or single-well throughput. Here, we report a semiconductor 96-microplate platform designed for high-resolution real-time impedance "imaging" at scale.

Technical Note: ID-card-size dosimeter based on radiochromic films for continuous personnel monitoring.

Purpose: This paper is aimed at investigating the feasibility of developing a personal dosimeter of cumulative radiation dose which would incorporate the following features: 1) a small size compared to that of a proximity ID card; 2) instant dose readout; 3) no power source; 4) moderate cost. The dosimeter is proposed as a potential replacement for TLD and OSL dosimeters used by nuclear industry workers and some medical staff groups.

Methods: An original detector design is developed containing a two-color LED, two photodetectors located in one plane covered with a mirror coating.

Reducing unintended consequences of e-prescribing on the path to nuanced prescriptions.

A frequency value of "as directed" was added to all medications available for an ambulatory EMR to reduce the number of prescriptions with contradictory instructions. The new frequency value has been rapidly adopted and its use has increased by 15%.

Weight-based pediatric prescribing in ambulatory setting.

Building on a foundation of a dose-based ambulatory prescribing system, an advanced weight-based pediatric prescribing module was successfully implemented. It provides a complete solution for calculating a dispensable dose and choosing optimal drug strength and form.

Implementing renal impairment and geriatric decision support in ambulatory e-prescribing.

An advanced decision support system for prescribing to patients with renal impairment and geriatric patients was successfully implemented in an ambulatory electronic medical record (EMR) system.