Publications by authors named "Alexander A Modestov"
DNA Repair (Amst)
March 2023
Article Synopsis
- DNA repair mechanisms are crucial for maintaining genome integrity and limiting tumor progression, but they can also help tumors survive radiation and chemotherapy treatments.
- Research analyzed 38 DNA repair pathways across nine cancer types using RNAseq data from various databases, revealing a consistent downregulation of the G2/M checkpoint pathway and low p53 pathway activity in tumors.
- The study identified that despite most DNA repair pathways being upregulated, key genes associated with the G2/M checkpoint and p53 pathways were significantly disrupted, highlighting their unique roles in cancer development.
