Publications by Alexander A Cheblokov

Publications by authors named "Alexander A Cheblokov"

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Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease.

Alena E Kopytova George N Rychkov Alexander A Cheblokov Elena V Grigor'eva Mikhail A Nikolaev

Int J Mol Sci

May 2023

Mutations in the gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), cause Gaucher disease (GD) and are the most common genetic risk factor for Parkinson's disease (PD). Pharmacological chaperones (PCs) are being developed as an alternative treatment approach for GD and PD. To date, NCGC00241607 (NCGC607) is one of the most promising PCs.

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- Alexander A Cheblokov's recent research focuses on the interaction of pharmacological chaperones, particularly NCGC00241607, with mutant β-glucocerebrosidase, which is linked to Gaucher disease and Parkinson's disease.
- The study highlights the potential binding sites of NCGC00241607 on the enzyme, suggesting its applicability as a therapeutic option for managing the conditions.
- Results from patient-derived cell cultures indicate the efficacy of this pharmacological chaperone, reinforcing its potential as a viable treatment alternative for patients suffering from these genetic disorders.

Publications by authors named "Alexander A Cheblokov"

Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease.

Synopsis of recent research by authors named "Alexander A Cheblokov"