Appendiceal mucocele and pseudomyxoma peritonei; the clinical boundaries of a subtle disease.

Patient: Male, 70 • Male, 84.

Final Diagnosis: Appendiceal mucocele and pseudomyxoma peritonei.

Symptoms: -.

Pleiotropic effects of the acute and chronic inhibition of the renin-angiotensin system in hypertensives.

Renin-angiotensin system (RAS) inhibition may exert beneficiary pleiotropic effects on heart hemodynamics in hypertensive patients. We aimed to assess these effects on coronary flow reserve (CFR) and left ventricular (LV) filling pressure after acute and long-term treatment. Thirty-nine patients (48.

Circadian variation of blood pressure and heart rate in normotensives, white-coat, masked, treated and untreated hypertensives.

Introduction: Ambulatory blood pressure monitoring (ABPM) forms the basis for the diagnosis of masked hypertension, a condition associated with increased target organ damage, and of white-coat hypertension, a common condition among subjects referred to hypertensive centers. The aim of this study was to compare the circadian blood pressure (BP) and heart rate (HR) profiles in 1676 Greek subjects in order to identify the circadian patterns in these two categories of patient.

Methods: A total of 1676 subjects underwent 24-hour ABPM.

Impact of prehypertension on carotid artery intima-media thickening: actual or masked?

Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects.

Methods: A total of 807 subjects with office systolic BP<140 and diastolic BP<90mmHg, underwent 24h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements.

Inhibition of neurite outgrowth in N2a cells by leptophos and carbaryl: effects on neurofilament heavy chain, GAP-43 and HSP-70.

The neurodegenerative properties of the organophosphate ester leptophos (LEP) and the carbamate ester carbaryl (CB), both of which can cause neuropathic effects in animals, were investigated in differentiating mouse N2a neuroblastoma cells. At a sublethal concentration of 3 microM, both LEP and CB were able to inhibit the outgrowth of axon-like processes from N2a cells after only 4 h of exposure. Extracts of cells exposed to LEP showed decreased cross-reactivities with monoclonal antibodies that recognise the neurofilament heavy chain (NFH) and the growth-associated protein GAP-43.

The toxicity of chlorpyrifos towards differentiating mouse N2a neuroblastoma cells.

The aim of this work was to study the effects of chlorpyrifos (CPF) on the outgrowth of axons by differentiating mouse N2a neuroblastoma cells. This was achieved by morphological, Western blotting and enzymatic analyses of cells induced to differentiate in the presence and absence of CPF added either at the same time (co-differentiation) or 16 h after (post-differentiation) the induction of cell differentiation. The outgrowth of axon-like processes was impaired following 4 or 8 h exposure to CPF in both co- and post-differentiation experiments.

The transplacental effect of lead compounds on inorganic pyrophosphatase in brain, liver and kidneys of newborn rats.

The transplacental effect of tetraethyl lead or lead acetate on the activity of inorganic pyrophosphatase in brain, liver and kidneys of newborn rats varied with the organ, the lead compound, the dose, and the route and time of administration. Enzyme activity was usually decreased in brain and liver, suggesting adverse effects of lead on metabolism in these organs. The inorganic pyrophosphatase activity was generally increased in kidneys.

Effect of age on the seminal plasma and spermatozoa lead concentrations of bulls.

Blood, seminal plasma and spermatozoa lead concentrations were determined in Holstein (29 animals), Brown Swiss (14 animals) and Charoleux (11 animals) bulls aged 1-8 y. Blood concentrations were (mean +/- SD) 21.47 +/- 5.

Transplacental effect of lead compounds on tissue plasminogen activator activity, plasminogen activator inhibition and plasmin inhibition.

The transplacental effect of lead compounds (lead acetate and tetraethyl lead) on the tissue plasminogen activator activity (PAA), plasminogen activator inhibition (PAI) and plasmin inhibition (PI) was studied in the rat. The concentration of lead in organs of the newborn showed a great variation; the distribution of lead in the organs studied depended on the dose and the stage of gestation at injection. In each organ the concentration of lead was dose-dependent.

Demonstration of plasminogen activator activity in the intima and media of the normal human aorta and other large arteries: immunological identification of the plasminogen activator(s).

The plasminogen activator activity (PAA) in extracts of the intima, media, and adventitia of the normal human aorta and other large arteries (carotid artery, renal artery and iliac artery) was studied with a sensitive, quantitative spectrophotometric assay using plasminogen and the chromogenic plasmin substrate S-2251. All layers of the arteries showed PAA which was highest in the adventitia, lowest in the media, while in the intima (aorta) PAA was intermediate, but much closer to that of the media. Plasminogen activator inhibition (PAI) was at the same level in all layers of the arteries studied.