Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia.

. To describe cognitive assessment including social cognition in SPG4 patients. .

Amyloid-related imaging abnormalities in AβPP duplication carriers.

Immune response to vascular amyloid-β deposits leads to cerebral amyloid angiopathy related-inflammation (CAA-ri). Amyloid-related imaging abnormalities (ARIA) were initially reported during anti-amyloid trials and are associated with the APOE 4/4 genotype. We report the evolution of an AβPP duplication carrier with an APOE 3/3 genotype presenting ARIA-Effusion and then ARIA-Hemosiderin deposit, without anti-amyloid therapy, suggestive of a possible spontaneously resolutive CAA-ri (not neuropathologically proven).