CARMIL1-AA selectively inhibits macropinocytosis while sparing autophagy.

Macropinocytosis is reported to fuel tumor growth and drug resistance by allowing cancer cells to scavenge extracellular macromolecules. However, accurately defining the role of macropinocytosis in cancer depends on our ability to selectively block this process. 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) is widely used to inhibit macropinocytosis but affects multiple Na/H exchangers (NHE) that regulate cytoplasmic and organellar pH.

Conjunctivitis.

Conjunctivitis is the most common cause of red eye in primary care. The 3 most common types of conjunctivitis are viral, allergic, and bacterial, and they can present in either acute or chronic forms; the age of the patient, time of year and physical examination findings are paramount to distinguish the different types of conjunctivitis. Distinguishing between acute viral and bacterial conjunctivitis remains difficult.