Hotspots of Somatic Genetic Variation in Pituitary Neuroendocrine Tumors.

The most common genetic drivers of pituitary neuroendocrine tumors (PitNETs) lie within mutational hotspots, which are genomic regions where variants tend to cluster. Some of these hotspot defects are unique to PitNETs, while others are associated with additional neoplasms. Hotspot variants in and are the most common genetic causes of acromegaly and Cushing's disease, respectively.