Sensing Reactive Oxygen Species with Photoacoustic Imaging Using Conjugation-Extended BODIPYs.

Short-lived reactive intermediates such as reactive oxygen species (ROS) regulate many physiological processes, but overproduction can also lead to severe tissue dysfunction. Thus, there is a high demand for noninvasive detection of reactive molecules, which, however, is challenging. Herein, we report photoacoustic detection of ROS using conjugated BODIPY probes (ROS-BODIPYs).

Multispectral Optoacoustic Tomography of Benign and Malignant Thyroid Disorders: A Pilot Study.

This study aimed at evaluating hybrid multispectral optoacoustic tomography/ultrasound for imaging of thyroid disorders, including Graves' disease and thyroid nodules. The functional biomarkers and tissue parameters deoxygenated hemoglobin, oxygenated hemoglobin, total hemoglobin, saturation of hemoglobin, fat content, and water content were analyzed in thyroid lobes affected by Graves' disease ( = 6), thyroid lobes with healthy tissue ( = 8), benign thyroid nodules ( = 13), and malignant thyroid nodules ( = 3). In Graves' disease, significantly higher deoxygenated hemoglobin (3.