Publications by authors named "Alexa B Rangecroft"
Article Synopsis
- Metabolic syndrome is characterized by high lipid levels and cardiovascular issues, and this study explores the impact of inhibiting glycosphingolipid synthesis on a male mouse model of type II diabetes (db/db).
- The treatment with a specific glycosphingolipid inhibitor (BPD) resulted in reduced arterial thickness, lower levels of harmful lipids, and increased beneficial HDL levels in db/db mice over six weeks.
- Improved metabolic parameters were linked to enhanced gene expression related to cholesterol and fat metabolism, suggesting that targeting glycosphingolipid synthesis could be a promising strategy to manage metabolic syndrome and obesity, potentially applicable to humans.