Publications by authors named "Alexa Andewelt"
J Clin Endocrinol Metab
July 2002
Article Synopsis
- Leptin plays a crucial role in maintaining energy balance and is often deficient in severe lipodystrophy, leading to issues like insulin resistance and hormonal abnormalities.
- Seven diabetic female patients with low serum leptin were treated with recombinant leptin, resulting in significant improvements in menstrual cycle regularity and hormonal levels over four months.
- While some hormonal levels normalized, others like TSH showed a decrease, indicating that leptin therapy positively influenced certain aspects of hormonal regulation, but not others.
N Engl J Med
February 2002
Article Synopsis
- Leptin is a hormone regulating energy balance, and its deficiency in severe lipodystrophy leads to issues like diabetes and high triglycerides.
- Nine female patients with low leptin levels received recombinant leptin injections for four months, resulting in significantly higher serum leptin levels and improved health metrics.
- The treatment led to notable reductions in blood sugar levels, triglycerides, liver volume, and even decreased caloric intake, indicating that leptin therapy is beneficial for addressing metabolic problems in lipodystrophy.
