Publications by authors named "Alex von Kreigsheim"
Article Synopsis
- Molecular chaperones help proteins fold and assemble, but how they target specific proteins is still unclear.
- Research using mouse genetics reveals that ZMYND10 is a new co-chaperone that helps the FKBP8-HSP90 complex specifically assist axonemal dynein proteins, which are vital for cilia movement.
- Without ZMYND10, there's disruption in dynein stability, leading to wider degradation of motor components, and specific mutations in ZMYND10 can further complicate this process, suggesting that related diseases like primary ciliary dyskinesia should be viewed as specific types of protein misfolding disorders.
Focal adhesion kinase (FAK) mediates tumor cell-intrinsic behaviors that promote tumor growth and metastasis. We previously showed that FAK also induces the expression of inflammatory genes that inhibit antitumor immunity in the microenvironment. We identified a crucial, previously unknown role for the dual-function cytokine interleukin-33 (IL-33) in FAK-dependent immune evasion.
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