Publications by authors named "Alex Yuile"
Ther Drug Monit
June 2024
Article Synopsis
- Osimertinib, a drug for non-small cell lung cancer (NSCLC), can cause toxicity, leading to the need for dose adjustments; this study aimed to measure osimertinib and its active metabolites in dried blood spots (DBS) using a specialized hemaPEN device and compare results to plasma measurements.
- A validated method using ultrahigh-performance liquid chromatography-tandem mass spectrometry was developed to accurately quantify osimertinib and its metabolites from both plasma and DBS, demonstrating no significant bias linked to hematocrit levels in patient samples.
- The study concluded that measuring these drugs in DBS is a reliable and easier alternative for therapeutic drug monitoring, showing similar results to those obtained
