Publications by authors named "Alex Volovick"
The goal of this study was to determine the feasibility of focused ultrasound-based neuromodulation affecting auditory evoked potentials (AEPs) in animals. Focused ultrasound-induced suppression of AEPs was performed in 22 rats and 5 pigs: Repetitive sounds were produced, and the induced AEPs were recorded before and repeatedly after FUS treatment of the auditory pathway. All treated animals exhibited a decrease in AEP amplitude post-treatment in contrast to animals undergoing the sham treatment.
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- Recent studies focus on ultrasonic drug release, specifically using focused ultrasound (FUS) to increase the temperature at targeted tissue areas, enhancing drug delivery for cancer treatment.
- The research investigates the effect of heat and ultrasound on the effectiveness of the anticancer drug Doxorubicin (DOX) using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS) on human KB cells.
- Results indicate that elevated temperatures (above 41°C) combined with DOX significantly reduce cell viability, suggesting that heat increases drug penetration and ultrasound-induced cavitation can lead to cell necrosis, warranting further exploration and optimization of MRgFUS for improved drug delivery.