DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats.

Background: Dehydroepiandrosterone (DHEA) is an important precursor of active steroid hormone, produced abundantly by the adrenal cortex with an age-dependent pattern.

Objective: We investigated whether chronic DHEA administration impacts on redox status and on Akt protein activation in skeletal muscle during the aging process (3 and 24 months-old rats).

Methods: Rats received one weekly dose/5 weeks of DHEA (10 mg/kg) or vehicle.