Low intensity training improves redox status and reduces collagen fibers on dystrophic muscle.

Exercise therapy on skeletal muscle of muscular dystrophies has no defined parameters. The effect of low-intensity treadmill training on the oxidative stress markers and fibrosis on hindlimb muscles was investigated. Sixteen dystrophic male animals were separated in trained (T/n=8) and untrained (NT/n=8) groups.

Low-intensity training provokes adaptive extracellular matrix turnover of a muscular dystrophy model.

Recommendations of therapeutic exercise in Duchenne muscular dystrophy are still controversial. The hypothesis that a low-intensity training (LIT) protocol leads to muscle adaptations on mdx mice model was tested. Dystrophic male mice with 8 weeks old were separated in exercised (mdxE, n= 8) and sedentary (mdxC, n= 8) groups.