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Publications by authors named "Alex R Zhang"

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Synopsis of recent research by authors named "Alex R Zhang"

  • - Alex R Zhang's recent research focuses on the role of apolipoprotein E4 (APOE4) in the pathogenesis of Alzheimer's disease, particularly its effects on neuronal and network function in the hippocampus.
  • - The study identifies region-specific network hyperexcitability in young APOE4 knock-in (E4-KI) mice, suggesting that these changes may predict cognitive deficits that manifest in later life.
  • - Findings indicate that the hyperexcitability is associated with specific subpopulations of smaller, more excitable neurons in the hippocampus, which could be mitigated through the selective removal of neuronal APOE4.

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