Investigation of electrical stimulus on chitosan film based DDS.

Controlled drug release is crucial for targeted implant smart drug delivery system (DDS). In this work a chitosan film loaded with green food coloring is fabricated to demonstrate the concepts of drug release using electrical stimulus. A simulation model is also developed to explain the physical phenomena of this drug release using finite element method (FEM).

Institutional perspective on the impact of positive blood cultures on the economic and clinical outcomes of patients with complicated skin and skin structure infections: focus on gram-positive infections.

Background: Traditionally, skin and skin structure infections (SSSIs) have been viewed as having a lower risk of mortality, morbidity, and cost compared with other types of infection. The influence of secondary bacteremia on the medicoeconomic outcomes of patients with SSSIs has not been well described.

Objective: The goal of this study was to evaluate the impact of bacteremia complicating SSSIs on length of hospital stay and costs.

Hospitalizations with healthcare-associated complicated skin and skin structure infections: impact of inappropriate empiric therapy on outcomes.

Objective: Inappropriate empiric therapy worsens outcomes in certain healthcare-associated infections (HCAI). We studied the association of inappropriate empiric therapy with outcomes in patients with HCA complicated skin and skin structure infections (cSSSI).

Design: A single-center retrospective cohort study.

Bacteremia increases the risk of death among patients with soft-tissue infections.

Background: Soft-tissue infections traditionally have been viewed as carrying a lower risk of death than other types of infection such as pneumonia, blood stream, and intra-abdominal. The influence of secondary bacteremia on the outcomes of patients with soft-tissue infections is not well described.

Objectives: To describe the risk factors for bacteremia among patients admitted to an urban medical center with soft-tissue infections and the influence of bacteremia on outcomes.

Epidemiology and outcomes of hospitalizations with complicated skin and skin-structure infections: implications of healthcare-associated infection risk factors.

Objective: Healthcare-associated infections are likely to be caused by drug-resistant and possibly mixed organisms and to be treated with inappropriate antibiotics. Because prompt appropriate treatment is associated with better outcomes, we studied the epidemiology of healthcare-associated complicated skin and skin-structure infections (cSSSIs).

Patients: Persons hospitalized with cSSSI and a positive culture result.