Publications by authors named "Alex Neuwelt"
Article Synopsis
- N-acetylcysteine (NAC) and fomepizole are used to treat AAP toxicity and have shown effectiveness in preventing liver damage in experimental mice when AAP was administered at high doses.
- The study found that using fomepizole allowed for significantly higher doses of AAP to be given without liver toxicity, while also enhancing anticancer activity, suggesting a potential immune-mediated response in tumor reduction.
Background: Ferumoxytol, an FDA-approved superparamagnetic iron oxide nanoparticle (SPION) preparation used for the treatment of iron deficiency anemia, is also known to be taken up by macrophages in areas of infection or inflammation, where it produces negative contrast changes on T2-weighted MR images.
Purpose: We sought to compare Ferumoxytol-induced MRI contrast changes with those observed using standard-of-care Gadolinium in patients presenting with symptoms suggestive of osteomyelitis.
Subjects: Out of eighteen enrolled patients, 15 had MR imaging with both ferumoxytol and gadolinium.