Synopsis of recent research by authors named "Alex N Lagasse"
- Alex N LaGasse's research primarily investigates the implications of maternal nutrition on the health and metabolic functions of offspring, highlighting how caloric restriction during gestation and lactation can affect neonatal development and resistance to obesity in adult mice.
- The studies utilize advanced methodologies, including Cre-LoxP technology and fluorescence-activated cell sorting, to explore the mechanisms by which metabolic signals, such as leptin, regulate somatotroph cells in the pituitary gland, impacting growth hormone signaling.
- Findings indicate significant changes in the size and metabolic profiles of offspring related to maternal diet, with specific emphasis on altered transcript levels that may influence growth and body composition, as well as the broader implications of these effects on health outcomes.
