Synopsis of recent research by authors named "Alex Macpherson"
- Alex Macpherson's recent research focuses on the innovative design and characterization of bi- and multi-specific antibody constructs, leveraging unique structural features of bovine antibodies to enhance therapeutic efficacy and specificity for targets like serum albumin and complement proteins.
- Key findings include the development of small peptide fragments derived from bovine ultralong CDRH3 that exhibit potential for improved antigen binding, as well as the discovery of methods to engineer binding specificity through the manipulation of knob domain structures.
- Another significant area of exploration is the modulation of complement pathways via newly synthesized knob domain peptides, highlighting their promising role in therapeutic strategies for inflammation and immune response modulation.
