Community-acquired pneumonia in infants: Not simply an acute event with complete recovery.

Background: Pneumonia in infancy has been linked to long-term consequences for the rapidly developing lung. We examined the impact of hospitalized community-acquired pneumonia (CAP) on subsequent respiratory health.

Methods: We conducted a retrospective matched-cohort study using the Optum® de-identified Electronic Health Record Dataset (2009-2018).

Mortality and readmission in the year following hospitalization for pneumonia among US adults.

Background: Increasing evidence suggests the impact of pneumonia persists beyond hospital discharge and the acute phase of respiratory symptoms. We characterized short-term and long-term risks of mortality and hospital readmission across the adult age span and spectrum of comorbidities.

Methods: Retrospective cohort design and Optum's de-identified Integrated Claims-Clinical dataset (2012-2018) were employed.

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice.

Background: Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding events. The objectives of this study were to characterize the incidence, clinical consequences, and economic costs of CIT in current US clinical practice.

Methods: A retrospective cohort design and data from two US private healthcare claims repositories (01/2010-12/2016) were employed.