Determinants of repair type, reintervention, and mortality in 393 children with double-outlet right ventricle.

Objective: We sought to define the prevalence of definitive end-states and their determinants in children with double-outlet right ventricle.

Methods: We performed a clinical record review of 393 children with double-outlet right ventricle presenting to our institution from 1980 to 2000.

Results: Double-outlet right ventricle classification was as follows: subaortic ventricular septal defect with or without pulmonary stenosis in 47%, subpulmonic ventricular septal defect in 23%, noncommitted ventricular septal defect in 26%, and doubly committed ventricular septal defect in 4%.

Cell transplantation to improve ventricular function in the failing heart.

Current therapies for congestive heart failure are limited in efficacy or in applicability. Cardiac cell transplantation offers a novel therapeutic approach to improve heart function. Although significant progress has been made over the past decade in the development of cell transplantation, only recently have investigators studied the changes in ventricular function following cell transplantation.