Publications by authors named "Alex Kruswick"
Article Synopsis
- DNA double-strand breaks (DSBs) are repaired through various pathways, influencing genomic stability, cancer development, and genome editing techniques like CRISPR/Cas9.
- Researchers developed three fluorescent Cas9-based reporters, called DSB-Spectrum, to evaluate and differentiate the roles of multiple DNA repair pathways involved in DSB repair.
- Their findings reveal that inhibiting certain repair factors can shift the repair process towards more error-prone methods, highlighting the complexity of DSB repair and the potential of these new reporters for studying repair pathway interactions.
Recent integrative epigenome analyses highlight the importance of functionally distinct chromatin states for accurate cell function. How these states are established and maintained is a matter of intense investigation. Here, we present evidence for DNA damage as an unexpected means to shape a protective chromatin environment at regions of recurrent replication stress (RS).
View Article and Find Full Text PDFTumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessive cell division. Modulating repair factor function, thus, provides a promising strategy to manipulate malignant growth. Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA repair by homologous recombination.
View Article and Find Full Text PDF