Multiple myeloma recurrence with optic nerve infiltration diagnosed by vitrectomy, immunohistochemistry, and in situ hybridization.

Purpose: We present a case of multiple myeloma recurrence diagnosed by optic nerve infiltration.

Methods: Interventional case report with clinical, surgical, immunohistochemical, and fluorescence in situ hybridization correlation.

Results: A 51-year-old woman with a history of bilateral invasive ductal breast carcinoma and multiple myeloma, both in remission on maintenance bortezomib, was referred for sudden, painless loss of vision OS.

The effect of biomicroscope illumination system on grading anterior chamber inflammation.

Purpose: To determine how a biomicroscope illumination system affects the grading of anterior chamber (AC) inflammation.

Design: Laboratory investigation.

Methods: An artificial AC was designed to replicate optically a human AC and was filled with 5-mum polystyrene beads suspended in ethanol.

Triamcinolone acetonide preparations: impact of crystal size on in vitro behavior.

Purpose: To characterize the in vitro behavior of three preparations of triamcinolone acetonide (TA).

Methods: Three preparations of TA were mixed with Balanced Salt Solution Plus: commercially available TA (Kenalog 40, Bristol-Myers Squibb, Princeton, NJ), compounded preservative-free triamcinolone acetonide (PFTA, New England Compounding Center, Framingham, MA), and triamcinolone acetonide injectable suspension (TAIS, TRIESENCE, Alcon, Inc., Fort Worth, TX).

Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits.

Purpose: To investigate the pharmacokinetics of bevacizumab in rabbits for three different routes of administrations: intravitreal injection, subconjunctival injection, and eye drops.

Methods: Pigmented rabbits received bevacizumab in one eye by topical eye drops (1.25 mg/0.

Circulating anti-retinal antibodies as immune markers in age-related macular degeneration.

Age-related macular maculopathy (ARM) and age-related macular degeneration (AMD) are the leading causes of blindness in the Western world. Despite the magnitude of this clinical problem, very little is known about the pathogenesis of the disease. In this study, we analysed the sera (using indirect immunohistochemistry and Western blot analysis) from a very large cohort of such patients and normal age-matched controls to detect circulating anti-retinal antibodies.

Contour integration in peripheral vision reduces gradually with eccentricity.

Hess and Dakin reported that normally-sighted subjects using peripheral vision (beyond 10 degrees ) were unable to detect paths of alternating-phase Gabors embedded within randomly positioned Gabors, but could detect same-phase paths. This result led them to propose a "fundamental difference" between central and peripheral visual processing. While we were able to replicate many of their results, our normally-sighted observers could detect alternating-phase paths beyond 10 degrees.

Lateral interactions: size does matter.

Usually a high-contrast, co-local mask increases contrast threshold (inhibition). Interestingly, a laterally displaced mask (flanker) can facilitate contrast detection (Vision Research 33 (1993) 993; 34 (1994) 73). When spatial scaling of these flanker effects was implied, stimulus bandwidth was confounded with spatial frequency (lambda(-1)).