Predicting Malignancy Risk of Screen-Detected Lung Nodules-Mean Diameter or Volume.

Objective: In lung cancer screening practice low-dose computed tomography, diameter, and volumetric measurement have been used in the management of screen-detected lung nodules. The aim of this study was to compare the performance of nodule malignancy risk prediction tools using diameter or volume and between computer-aided detection (CAD) and radiologist measurements.

Methods: Multivariable logistic regression models were prepared by using data from two multicenter lung cancer screening trials.