Publications by authors named "Alex J Cappellini"
Staphylococcus aureus infections are hard to treat due to the emergence of antibiotic resistant strains, as well as their ability to form biofilms. The MazEF toxin-antitoxin system is thought play a role in bacterial biofilm phenotype as well as antibiotic resistance. In S.
View Article and Find Full Text PDFBoth and are commonly associated with periprosthetic joint infections (PJIs). The treatment of PJI can be challenging because biofilms are assumed to have an increased intolerance to antibiotics. This makes the treatment of PJI challenging from a clinical perspective.
View Article and Find Full Text PDFThe In Vitro Efficacy of Doxycycline over Vancomycin and Penicillin in the Elimination of Biofilm.
Antimicrob Comb Devices (2019)
November 2020
Article Synopsis
- The study focuses on the effectiveness of antibiotics—vancomycin, penicillin, and doxycycline—in treating periprosthetic joint infections caused by a specific pathogen during total shoulder arthroplasty, particularly in relation to bacterial biofilms.* -
- Findings reveal that doxycycline consistently achieves effective concentrations against both planktonic (free-floating) and biofilm-forming bacteria, whereas penicillin and vancomycin show significantly reduced efficacy, especially against biofilms.* -
- Doxycycline's minimum biofilm inhibitory concentration (MBIC) falls within the clinical dosing range for all tested strains, while penicillin manages this for only 60% and vancomycin for just 20% of the