Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air.

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Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.

Background: Asthma is a disease characterized by ventilation heterogeneity (VH). A number of studies have demonstrated that VH markers derived by using impulse oscillometry (IOS) or multiple-breath washout (MBW) are associated with key asthmatic patient-related outcome measures and airways hyperresponsiveness. However, the topographical mechanisms of VH in the lung remain poorly understood.