Publications by authors named "Alex Guano"
Article Synopsis
- Osteoclasts are essential for bone resorption, and their impairment due to HIV infection can significantly affect bone density in individuals living with HIV. This study explores how HIV influences the differentiation of osteoclasts from human monocyte-derived macrophages.
- The researchers analyzed the effects of HIV infection on various factors related to osteoclast differentiation, including cellular adhesion, cathepsin K expression, resorptive activity, and cytokine production, using profiles of co-receptors and transcriptional regulation of key factors.
- Findings showed that severe HIV infection drastically hinders osteoclast differentiation by impacting their cellular adhesion and activity while promoting an earlier and more suppressed production of critical cytokines, indicating a
Osteoarticular injury is the most common presentation of active brucellosis in humans. Osteoblasts and adipocytes originate from mesenchymal stem cells (MSC). Since those osteoblasts are bone-forming cells, the predilection of MSC to differentiate into adipocytes or osteoblasts is a potential factor involved in bone loss.
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