A spatially continuous diffusion model of visual working memory.

We present results from five visual working memory (VWM) experiments in which participants were briefly shown between 2 and 6 colored squares. They were then cued to recall the color of one of the squares and they responded by choosing the color on a continuous color wheel. The experiments provided response proportions and response time (RT) measures as a function of angle for the choices.

Does response modality influence conflict? Modelling vocal and manual response Stroop interference.

In the Stroop task, color words are presented in colored fonts and the task of the subject is to either name the word or name the color. If the word and font color are in agreement, then the stimulus is said to be congruent (e.g.

The telomere bouquet regulates meiotic centromere assembly.

The role of the conserved meiotic telomere bouquet has been enigmatic for over a century. We showed previously that disruption of the fission yeast bouquet impairs spindle formation in approximately half of meiotic cells. Surprisingly, bouquet-deficient meiocytes with functional spindles harbour chromosomes that fail to achieve spindle attachment.

Telomeres and centromeres have interchangeable roles in promoting meiotic spindle formation.

Telomeres and centromeres have traditionally been considered to perform distinct roles. During meiotic prophase, in a conserved chromosomal configuration called the bouquet, telomeres gather to the nuclear membrane (NM), often near centrosomes. We found previously that upon disruption of the fission yeast bouquet, centrosomes failed to insert into the NM at meiosis I and nucleate bipolar spindles.

A single internal telomere tract ensures meiotic spindle formation.

Contact between telomeres and the fission yeast spindle pole body during meiotic prophase is crucial for subsequent spindle assembly, but the feature of telomeres that confers their ability to promote spindle formation remains mysterious. Here we show that while strains harbouring circular chromosomes devoid of telomere repeat tracts undergo aberrant meiosis with defective spindles, the insertion of a single internal telomere repeat stretch rescues the spindle defects. Moreover, the telomeric overhang-binding protein Pot1 is dispensable for rescue of spindle formation.